Glucose 6 Phosphate Dehydrogenase: Update and Analysis of New Mutations around the World Glucose 6 phosphate dehydrogenase deficiency pathophysiology wikidoc Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione