Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Lyuh Esther Liposome Glutathione Direct Ultra X, Health & Nutrition, Health Supplements, Vitamins & Supplements on Carousell Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.