Drug Metabolism Synthetic (Phase II) Reactions Springer Nature Link Glutathione Conjugation GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY The role of glutathione S transferase in anti cancer drug resistance Oncogene
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glutathione conjugation reaction Solved The stepwise mechanism below shows how glutathione