Acetaminophen Toxicity Toxicology UWorld Medical Library Glutathione Deficiency Symptoms: Is Poor Sleep Just the Beginning? Cardiology & Neurology Specialists located in Queens, Forest Hills and Brighton Beach, Brooklyn, NY Advanced Medical Care We know that *glutathione* is what detoxifies NAPQI. So, why must we give its precursor, N acetylcysteine (NAC), instead of just giving glutathione directly? A. Glutathione has poor bioavailability and cannot enter the Too Much of a Good Thing: Inadvertent Acetaminophen Overdose in a Low Weight, Elderly Patient